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MEDICAL NEWS:
Abstract

Background  African-American women have the highest breast (boob) cancer death rates of all racial/ethnic groups in the US. Reasons for these
disparities are multi-factorial, but include lower mammogram utilization among this population. Cultural attitudes and beliefs,
such as fear and fatalism, have not been fully explored as potential barriers to mammography among African-American women.

Objective  To [...]

MEDICAL NEWS: If a trial is adequately powered for two clinically important endpoints, A and B, each of which can fully characterize a treatment benefit to support a regulatory claim by itself, then both endpoints are usually labeled primary, and the trial is deemed positive if either endpoint is statistically significant after a multiplicity [...]

Hospitals & Doctors:
SACRAMENTO, CALIF. (August 29, 2008) - The UnivER (Emergency Room)sity of California, Davis, School of Medicine has been ranked numbER (Emergency Room) 10 among all medial schools in the United States in the annual survey of best graduate schools for Latino students conducted by Hispanic Business magazine.

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UC Davis School of Medicine [...]

CANCER NEWS: Well, it has been a couple months since we posted anything here…..you know it really is true…life does go on! Valerie had implants put in last October, and with all the changes her body went through after Chemo and Radiation, they (the implants) have decided not to cooperate. So, Valerie is scheduled [...]

CANCER NEWS: Well, it has been a couple months since we posted anything here…..you know it really is true…life does go on! Valerie had implants put in last October, and with all the changes her body went through after Chemo and Radiation, they (the implants) have decided not to cooperate. So, Valerie is scheduled [...]

CANCER NEWS: As of early Sunday morning, Jill Biden took on a new title: possible Vice Presidential wife. (“Second Lady” sounds so tacky, doesn’t it?) And if she and husband Joe move into Blair House come January 2009, she’ll assume a whole new set of responsibilities. But I’m betting she’ll keep a firm grip [...]

CANCER NEWS: IntroductionPatients with primary operable estrogen receptor negative (ER-) breast (women’s) cancer account for approximately 30% of all cases and generally have worse prognosis (outlook) than ER+ patients. Nevertheless, a significant proportion of ER- cases have favourable outcome and could potentially benefit from a less aggressive course of therapy. Identification of such good [...]

CANCER NEWS: PALO ALTO, Calif. — Telik, Inc. announced today that its novel small molecule proteasome inhibitor program met a preclinical development milestone by demonstrating anticancer activity in preclinical models of human leukemia. The proteasome is an important cellular structure necessary for the growth and function of cancer cells and inhibition of the proteasome [...]

MEDICAL NEWS: The ADEPT software package is not a statistical method in its own right as implied by Gerke and Siedentop (Statist. Med. 2008; DOI: ). ADEPT implements two-parameter CRM models as described in O’Quigley et al. (Biometrics 1990; 46(1):33-48). All of the basic ideas (use of a two-parameter logistic model, use of a [...]

MEDICAL NEWS: Partial verification refers to the situation where a subset of patients is not verified by the reference (gold) standard and is excluded from the analysis. If partial verification is present, the observed (naive) measures of accuracy such as sensitivity and specificity are most likely to be biased. Recently, Harel and Zhou showed [...]

MEDICAL NEWS: Partial verification refers to the situation where a subset of patients is not verified by the reference (gold) standard and is excluded from the analysis. If partial verification is present, the observed (naive) measures of accuracy such as sensitivity and specificity are most likely to be biased. Recently, Harel and Zhou showed [...]

MEDICAL NEWS: This article presents a new approach to the problem of deriving an optimal design for a randomized group sequential clinical trial based on right-censored event times. We are motivated by the fact that, if the proportional hazards assumption is not met, then a conventional design’s actual power can differ substantially from its [...]