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CANCER NEWS: COPENHAGEN, Denmark — Genmab has announced plans to begin four studies of ofatumumab in chronic lymphocytic leukemia and non-Hodgkin’s lymphoma. Genmab A/S announced today plans to begin four studies of ofatumumab in chronic lymphocytic leukemia (CLL) and follicular non-Hodgkin’s lymphoma (NHL) this year. “Genmab and GSK have worked diligently to expand the [...]

(Mesothelioma News) BOTHELL, WA and VANCOUVER — OncoGenex Pharmaceuticals announced today that OGX-011, also known as custirsen sodium, received Fast Track designation from the U.S. Food & Drug Administration (FDA) in combination with docetaxel for progressive metastatic prostate cancer. OGX-011 is currently completing five Phase 2 clinical studies in prostate, lung and breast cancer, and [...]

DRUGS & RX: Studies demonstrate efficacy and safety of VisonacTM and the potential for a simplified Photodynamic Therapy (PDT) procedure for treatment of moderate to severe acne
Oslo, Norway, August 27, 2008 - Photocure announces positive preliminary results…

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Photocure Announces Positive Phase II Results with Visonac for Acne was another wonderful and [...]

DRUGS & RX: Studies from pramipexole clinical programme confirm efficacy in treating highly prevalent RLS-associated symptoms, including limb pain and mood disturbance
Ingelheim, Germany, 26 August 2008 - Results from a large pramipexole trial programme in…

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Pramipexole Clinical Trial Programme in Restless Legs Syndrome (RLS) Reveals New Significant Results was another wonderful [...]

VIOXX CLASS ACTION LAWSUIT UPDATE: A Vioxx study that was supposedly meant to find out if the recalled painkiller was less likely to cause stomach problems than another drug was really nothing more than a marketing ploy, a new report says.   According to (Vioxx maker) Merck & Co. memos and reports obtained during Vioxx [...]

CANCER NEWS: Background
Candidaspongiolide (CAN), a novel polyketide from a marine sponge, is the active component of a mixture that was found to be potently cytotoxic in the National Cancer Institute’s 60-cell-line screen.

Methods
Effects of CAN on U251 glioma and HCT116 colorectal cancer cells and on normal fibroblasts were assessed using radiolabeling studies to measure protein [...]

CANCER NEWS: Background
Cancer-related fatigue is an important clinical problem. It is common, distressing, and often difficult to treat. There is a role for Dr. (God)g treatment of cancer-related fatigue, but no consensus has been reached on which Dr. (God)gs are useful. This systematic review and meta-analysis aims to review the available evidence and make [...]

MEDICAL NEWS: With the advent of continuous subcutaneous insulin infusion therapy and the findings of the Diabetes Control and Complications Trial, the management of type 1 diabetes has changed drastically. Over the past 30 years since its development, the effectiveness of continuous subcutaneous insulin infusion has been assessed in comparison with other modes of [...]

MEDICAL NEWS:
Background: An inverse association between physical activity and metabolic syndrome has been reported in several cohorts, but very few specific studies are available in the elderly, in whom neurological and musculo-skeletal diseases are expected to lead to a remarkable age-related decline of physical activity.
Aim and Design: The relationships among physical activity, insulin resistance and [...]

MEDICAL NEWS:
Objective: In severe paracetamol hepatotoxicity, orthotopic liver transplant (OLT) is a standard treatment in patients judged to have a hopeless prognosis. The most commonly used criteria to make this decision are the King’s College Criteria (KCC). We aimed to compare the expected survival for patients who meet the KCC and do not receive transplant [...]

MEDICAL NEWS: SuperGen, Inc., a pharmaceutical compaNY (New York) dedicated to the discovery, rapid development and commercialization of therapies for solid tumors and hematological malignancies, announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for the compaNY (New York)’s lead drug candidate, MP-470, for the treatment of glioblastoma multiforme [...]

MEDICAL NEWS: Researchers detail in ‘Induction therapy in the modern era of combined-modality therapy for locally advanced head and neck cancer,’ new data in head and neck cancer. “As therapy for locoregionally advanced head and neck cancer (HNC) has evolved, treatment has become increasingly aggressive and cure rates have risen. However, survival still remains [...]