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CANCER NEWS: The hypothesis that cancer stem cells are responsible for the chemo-resistant and metastatic phenotypes of many breast (women’s) cancers has gained support using cell sorting strategies to enrich for the tumor-initiating population of cells. However, the mechanisms regulating the cancer stem cell pool are less clear. Two recent publications suggest that loss [...]

CANCER NEWS: Australian scientists have identified a way to ’switch off’ a molecule, a key player in the molecular processes that trigger breast (women’s) cancer and certain forms of leukemia. The molecule, known as Gab2, operates downstream of a major breast (women’s) cancer oncogene, HER2, the target of the Dr. (God)g Herceptin. A research [...]

CANCER NEWS: PALO ALTO, Calif. — Telik, Inc. announced today that its novel small molecule proteasome inhibitor program met a preclinical development milestone by demonstrating anticancer activity in preclinical models of human leukemia. The proteasome is an important cellular structure necessary for the growth and function of cancer cells and inhibition of the proteasome [...]

CANCER NEWS: Micromet, Inc., a biopharmaceutical company developing novel, proprietary antibodies for the treatment of cancer, inflammation and autoimmune diseases, announced publication of a Phase 1 clinical study(1) on its BiTE(R) antibody blinatumomab (MT103/MEDI-538) in this week’s issue of Science. The article is available at www.sciencemag.org. Blinatumomab is being co-developed with MedImmune. Blinatumomab is [...]

CANCER NEWS: Stem cell scientists in the region have helped to develop a more accurate way of identifying aggressive forms of bowel cancer, which should eventually lead to better treatment and improved survival rates. The UK-led team, headed by scientists from Durham University and the North-East England Stem Cell Institute, (NESCI), studied tissue samples [...]

(Mesothelioma News) ROCKVILLE, Md. — Human Genome Sciences, Inc. today announced that it has completed the enrollment and initial dosing of patients in a randomized Phase 2 trial of HGS-ETR1 (mapatumumab) in combination with the chemotherapy (serious, serious drugs) agents paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer (NSCLC). “There is [...]

(Mesothelioma News) The biotech company that Justin Murdock, the son of Dole Food Co. owner David Murdock, leads has begun stage-III clinical trials for a lung cancer vaccine. NovaRx, based in San Diego, is testing its Lucanix vaccine in about 700 patients with lung cancer — a disease which the American Cancer Society says is [...]

DRUGS & RX: INDIANAPOLIS, August 26, 2008 /PRNewswire/ — Semafore Pharmaceuticals Inc. announced data presented at the Seventh International Congress on Targeted Therapies in Cancer in Washington, D.C., showing additional antiangiogenic activity of…

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SF1126, Semafore’s PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell [...]

DRUGS & RX: MELBOURNE, Australia, Aug 21, 2008 - (ABN Newswire) - Australian regenerative medicine company Mesoblast Limited (ASX:MSB)(PINK:MBLTY), today announced that its allogeneic, or “off-the-shelf”, cell therapy…

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Mesoblast Limited’s (ASX:MSB) Allogeneic, "Off-The-Shelf", Stem Cells Are Safe And Effective For Cervical Spine Fusion was another wonderful and informative drug and pharmaceutical [...]

DRUGS & RX: LONDON, Aug. 20, 2008–A new drug for cystic fibrosis, PTC124, can bypass the genetic defect in the protein-making machinery of patients and improve the functioning of cell membranes that is normally hampered by the condition. These are the…

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New Drug for Cystic Fibrosis Bypasses Genetic Defect and Improves [...]

DRUGS & RX: SOUTH SAN FRANCISCO, Calif.–(BUSINESS WIRE)–Aug 27, 2008 - Cell Genesys, Inc. (Nasdaq:CEGE) today announced that it has terminated VITAL-2, the second of two Phase 3 clinical trials of GVAX immunotherapy for prostate cancer, which compares GVAX…

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Cell Genesys Halts VITAL-2 GVAX Trial in Advanced Prostate Cancer was another [...]

CANCER NEWS: Background:
Childhood pre-B acute lymphoblastic leukemia (ALL) is a bone marrow (BM) derived disease, which often disseminates out of the BM cavity, where malignant (not good) cells to a variable degree can be found circulating in the peripheral blood (PB). Normal pre-B cells are absolutely dependent on BM stroma for survival and differentiation. [...]