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CANCER NEWS: IntroductionPatients with primary operable estrogen receptor negative (ER-) breast (women’s) cancer account for approximately 30% of all cases and generally have worse prognosis (outlook) than ER+ patients. Nevertheless, a significant proportion of ER- cases have favourable outcome and could potentially benefit from a less aggressive course of therapy. Identification of such good [...]

MEDICAL NEWS: Partial verification refers to the situation where a subset of patients is not verified by the reference (gold) standard and is excluded from the analysis. If partial verification is present, the observed (naive) measures of accuracy such as sensitivity and specificity are most likely to be biased. Recently, Harel and Zhou showed [...]

MEDICAL NEWS: Partial verification refers to the situation where a subset of patients is not verified by the reference (gold) standard and is excluded from the analysis. If partial verification is present, the observed (naive) measures of accuracy such as sensitivity and specificity are most likely to be biased. Recently, Harel and Zhou showed [...]

MEDICAL NEWS: This article presents a new approach to the problem of deriving an optimal design for a randomized group sequential clinical trial based on right-censored event times. We are motivated by the fact that, if the proportional hazards assumption is not met, then a conventional design’s actual power can differ substantially from its [...]

DRUGS & RX: PARSIPPANY, N.J.–(BUSINESS WIRE)–Aug 26, 2008 - The Medicines Company (NASDAQ: MDCO) announced that a sub-analysis of the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) study, published in the September 2, 2008 issue of the…

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ACUITY 1-Year Sub-Analysis Published in Journal of the American College of Cardiology was [...]

DRUGS & RX: New analysis of landmark study showed patients taking prasugrel had lower risk of combined endpoint of recurrent heart attack, stroke or cardiovascular death after first event than those taking clopidogrel
TOKYO and INDIANAPOLIS, August 21, 2008…

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Head-to-Head Study Showed Prasugrel Statistically Superior to Clopidogrel in Reducing Recurrent Cardiovascular Events [...]

VIOXX CLASS ACTION LAWSUIT UPDATE: A Vioxx study that was supposedly meant to find out if the recalled painkiller was less likely to cause stomach problems than another drug was really nothing more than a marketing ploy, a new report says.   According to (Vioxx maker) Merck & Co. memos and reports obtained during Vioxx [...]

CANCER NEWS: Background
Individuals with a personal history of nonmelanoma skin cancer (NMSC) may have an increased risk of subsequent noncutaneous malignancies. To test this hypothesis, we carried out a community-based, prospective cohort study.

Methods
In the CLUE (Give Us a Clue to Cancer and Heart Disease) II cohort, which was established in Washington County, MD, in [...]

CANCER NEWS: Background
Leukemia evolves through a multistep process from premalignancy to malignancy. Epigenetic alterations, including histone modifications, have been proposed to play an important role in tumorigenesis. The involvement of two chromatin remodeling genes, retinoblastoma-binding protein 1 (Rbbp1/Arid4a) and Rbbp1-like 1 (Rbbp1l1/Arid4b), in leukemogenesis was not characterized.

Methods
The leukemic phenotype of mice deficient for Arid4a [...]

CANCER NEWS: Background
The risk of hepatocellular carcinoma (HCC) increases with increasing level of hepatitis B virus (HBV) in serum (viral load). However, it is unclear whether genetic characteristics of HBV, including HBV genotype and specific genetic mutations, contribute to the risk of HCC. We examined the HCC risk associated with HBV genotypes and common [...]

CANCER NEWS: Background
Cancer-related fatigue is an important clinical problem. It is common, distressing, and often difficult to treat. There is a role for Dr. (God)g treatment of cancer-related fatigue, but no consensus has been reached on which Dr. (God)gs are useful. This systematic review and meta-analysis aims to review the available evidence and make [...]

MEDICAL NEWS:
Aim: To examine trends in the prevalence of myocardial infarction (MI) and conventional risk factors in Greek adults between 2002 and 2006.
Design: Repeated cross-sectional study.
Methods: Self-reported data from surveys given in Salamis during two election days in 2002 and 2006 were analysed. The same sampling method and procedures were used on both surveys. The [...]