iHateHospitals.com

MEDICAL NEWS:
Abstract

Background  Physicians, influenced by various pressures, may document information in patient records that they did not personally observe.

Objective  To evaluate the hospital chart documentation practices of internists and internal medicine sub-specialists in the Northeastern
United States.

Design  An anoNY (New York)mous mail survey questionnaire.

Participants  One thousand one hundred twenty-six randomly selected internists and internal medicine sub-specialists.
[...]

MEDICAL NEWS:
Abstract

Background  African-American women have the highest breast (boob) cancer death rates of all racial/ethnic groups in the US. Reasons for these
disparities are multi-factorial, but include lower mammogram utilization among this population. Cultural attitudes and beliefs,
such as fear and fatalism, have not been fully explored as potential barriers to mammography among African-American women.

Objective  To [...]

MEDICAL NEWS:
Brief Report: Coronary Heart Disease Events Associated with Hormone Therapy in Younger and Older Women

Content Type Journal Article
Category Erratum
DOI 10.1007/s11606-008-0762-2
Authors

Shelley R. Salpeter, Santa Clara Valley Medical Center Department of Medicine San Jose CA USA
Judith M. E. Walsh, University of California, San Francisco Department of Medicine San Francisco CA USA
Elizabeth Greyber, Santa Clara Valley Medical [...]

MEDICAL NEWS: If a trial is adequately powered for two clinically important endpoints, A and B, each of which can fully characterize a treatment benefit to support a regulatory claim by itself, then both endpoints are usually labeled primary, and the trial is deemed positive if either endpoint is statistically significant after a multiplicity [...]

MEDICAL NEWS: The ADEPT software package is not a statistical method in its own right as implied by Gerke and Siedentop (Statist. Med. 2008; DOI: ). ADEPT implements two-parameter CRM models as described in O’Quigley et al. (Biometrics 1990; 46(1):33-48). All of the basic ideas (use of a two-parameter logistic model, use of a [...]

MEDICAL NEWS: Partial verification refers to the situation where a subset of patients is not verified by the reference (gold) standard and is excluded from the analysis. If partial verification is present, the observed (naive) measures of accuracy such as sensitivity and specificity are most likely to be biased. Recently, Harel and Zhou showed [...]

MEDICAL NEWS: Partial verification refers to the situation where a subset of patients is not verified by the reference (gold) standard and is excluded from the analysis. If partial verification is present, the observed (naive) measures of accuracy such as sensitivity and specificity are most likely to be biased. Recently, Harel and Zhou showed [...]

MEDICAL NEWS: This article presents a new approach to the problem of deriving an optimal design for a randomized group sequential clinical trial based on right-censored event times. We are motivated by the fact that, if the proportional hazards assumption is not met, then a conventional design’s actual power can differ substantially from its [...]

MEDICAL NEWS: Background:
Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert forms (cortisone), allows increased access of maternal glucocorticoids to the fetus and ‘programs’ hypertension. Data in humans are limited. We examined in humans the association between venous umbilical cord blood [...]

(Mesothelioma News) ROCKVILLE, Md. — Human Genome Sciences, Inc. today announced that it has completed the enrollment and initial dosing of patients in a randomized Phase 2 trial of HGS-ETR1 (mapatumumab) in combination with the chemotherapy (serious, serious drugs) agents paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer (NSCLC). “There is [...]

(Mesothelioma News) BOTHELL, WA and VANCOUVER — OncoGenex Pharmaceuticals announced today that OGX-011, also known as custirsen sodium, received Fast Track designation from the U.S. Food & Drug Administration (FDA) in combination with docetaxel for progressive metastatic prostate cancer. OGX-011 is currently completing five Phase 2 clinical studies in prostate, lung and breast cancer, and [...]

(Mesothelioma News) The biotech company that Justin Murdock, the son of Dole Food Co. owner David Murdock, leads has begun stage-III clinical trials for a lung cancer vaccine. NovaRx, based in San Diego, is testing its Lucanix vaccine in about 700 patients with lung cancer — a disease which the American Cancer Society says is [...]